| ESR1 | 
     Ishikawa (endometrial adenocarcinoma)  | 
     1 h with 10 nM Estradiol (Myers)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ENCSR000BIY
              
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     1 h with 100 nM Genistein (Myers)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ENCSR000BJS
              
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     Ishikawa (endometrial adenocarcinoma)  | 
     1 h with 100 nM Genistein (Myers)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ENCSR000BKL
              
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     1 h with 10 nM Estradiol (Myers)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ENCSR000BKN
              
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     1 h with 0.02% Dimethyl sufloxide (DMSO) (Myers)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ENCSR000BLL
              
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     100nM bisphenol A (CHEBI:33216) for 30 minute  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ENCSR000BQD
              
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     Ishikawa (endometrial adenocarcinoma)  | 
     1 h with 100 nM Bisphenol A (Myers)  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ENCSR000BQR
              
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     hormone starved for 3 days, treated with 1% ethanol for 45 minutes  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE19013
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     hormone starved for 3 days, treated with 10 nM β-estradiol for 45 minutes  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE19013
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE26083
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Estrogen  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE24166
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     ETOH (ethanol)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE23893
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE23893
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     ETOH (ethanol)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE23893
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     ETOH (ethanol)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE23893
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     Ishikawa (endometrial adenocarcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE23893
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     Ishikawa (endometrial adenocarcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE23893
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     ECC-1 (endometrial adenocarcinoma)  | 
     ETOH (ethanol)  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE23893
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     ECC-1 (endometrial adenocarcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE23893
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     H3396 (breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE32332
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     H3396 (breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE32332
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     H3396 (breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE32332
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     H3396 (breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE32332
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     oestrogen  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE25021
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     vehicle  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE25021
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     uterus  | 
     vehicle  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE36455
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     uterus  | 
     estradiol  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE36455
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     mammary cells  | 
     untreated  | 
    
      
      
      Permissive
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE46123
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     mammary cells  | 
     Dexamethasone for 30 minutes  | 
    
      
      
      Permissive
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE46123
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     mammary cells  | 
     Estradiol for 30 minutes  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE46123
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     mammary cells  | 
     Dexamethasone + Estradiol for 30 minutes  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE46123
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     mammary cells  | 
     Estradiol for 30 minutes  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE46123
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     mammary cells  | 
     Dexamethasone + Estradiol for 30 minutes  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE46123
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     7438 (mammary carcinoma)  | 
     untreated  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE46123
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     7438 (mammary carcinoma)  | 
     Estradiol for 30 minutes  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE46123
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     7438 (mammary carcinoma)  | 
     Dexamethasone + Estradiol for 30 minutes  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE46123
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     aortic cells  | 
     10 nM beta-estradiol (E2)  | 
    
      
      
      Permissive
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE52351
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     liver  | 
     10 nM beta-estradiol (E2)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE52351
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     liver  | 
     10 nM beta-estradiol (E2)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE52351
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     uterine cells  | 
     saline vehicle  | 
    
      
      
      Permissive
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE56466
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     none  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE60517
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     none  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE60517
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     LTED (breast cancer)  | 
     none  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE60517
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     LTED (breast cancer)  | 
     none  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE60517
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     1hr with ethanol, crosslinked with 1% formaldehyde  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE62222
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     1hr with 100nM E2, crosslinked with 1% formaldehyde  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE62222
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     cells transfected with siNCAPG, and 1hr with 100nM E2, double crosslinked  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE62222
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     cells transfected with siNCAPD3 and H2 together, and 1hr with 100nM E2, double crosslinked  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE62222
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     cells transfected with siCTL, and 1hr with 100nM E2, double crosslinked  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE62222
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Vehicle  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68357
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68357
              
            
          
            
            ...
            
          
            
          
            
          
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2+PG  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68357
              
            
          
            
            ...
            
          
            
          
            
          
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     liver  | 
     Placebo  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE70346
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     liver  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE70346
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     liver  | 
     E2, ER KO  | 
    
      
      
      Permissive
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE70346
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     sgRNA_enh588  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE75779
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     sgRNA_enh588  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE75779
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     100nM E2, 120min  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE76893
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Vehicle treatment  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE78284
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2 treatment  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE78284
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Vehicle treatment  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE78284
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2 treatment  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE78284
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     Vehicle  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE80367
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     10 nM Estradiol  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE80367
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     10 nM R5020  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE80367
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     10nM Estradiol + 10 nM R5020  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE80367
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     Vehicle  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE80367
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     10 nM Estradiol  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE80367
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     10 nM R5020  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE80367
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     10nM Estradiol + 10 nM R5020  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE80367
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     DMSO  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE80728
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE80728
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     DMSO  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE80728
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE80728
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     tumor A  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE81213
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     tumor C  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE81213
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     tumor D  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE81213
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     tumor E  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE81213
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     tumor B  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE81213
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     uterus  | 
     IGF1  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE100023
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     uterus  | 
     ICI 182,780  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE100023
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     U2OS (osteosarcoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE26110
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     IKK7  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE67295
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     IL1b+IKK7  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE67295
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2+ICI  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE67295
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     IL1b+ICI  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE67295
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2 for 45m  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE67295
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     IL1b for 45m  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE67295
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     TNFa for 45m  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE67295
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     ICI  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE81510
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE81510
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2, DEX  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE81510
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     DMSO  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE84593
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     BYL719  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE84593
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     control; 100 nM 17-beta-estradiol for 0h  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE85106
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     100 nM 17-beta-estradiol for 45 min  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE85106
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     100 nM 17-beta-estradiol for 3h  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE85106
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     siCTCF  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE85106
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     siNT  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE85106
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     White Medium + E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE86538
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 TamR (invasive ductal breast carcinoma Tamoxifen resistant)  | 
     White Medium  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE86538
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     White Medium  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE86538
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     White Medium + E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE86538
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     breast tumor xenograft  | 
     estrogen  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE93108
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     breast tumor xenograft  | 
     estrogen plus progesterone  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE93108
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     NoTreat  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94023
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     5min E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94023
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     10min E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94023
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     20min E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94023
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     40min E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94023
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     80min E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94023
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     160min E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94023
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     320min E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94023
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     640min E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94023
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     1280min E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94023
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     Tamoxifen-associated  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94031
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     Tamoxifen-associated  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94031
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     Tamoxifen-associated  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94031
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     Tamoxifen-associated  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94031
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     Tamoxifen-associated  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94031
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     Tamoxifen-associated  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94031
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Doxycycline  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Doxycycline + E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Doxycycline  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Doxycycline  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Doxycycline + E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Doxycycline + E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Doxycycline  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Doxycycline + E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     Doxycycline  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     Doxycycline + E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     none  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Doxycycline  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Doxycycline + E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94493
              
            
          
            
            ...
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     uterus  | 
     250 ng of estradiol (E2); mutant ERa  | 
    
      
      
      Permissive
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE94737
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 TamR (invasive ductal breast carcinoma Tamoxifen resistant)  | 
     vehicle  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE25710
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE25710
              
            
          
            
            ...
            
          
            
          
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     siNT  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE25710
              
            
          
            
            ...
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     siFOXA1  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE25710
              
            
          
            
            ...
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Cocktail_90  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE32222
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 TamR (invasive ductal breast carcinoma Tamoxifen resistant)  | 
     Tam-Resist  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE32222
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     BT-474 (breast invasive ductal carcinoma)  | 
     Tam-Resist  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE32222
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     ZR-75-1 (invasive ductal carcinoma)  | 
     Tam-Responsive  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE32222
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Tam-Responsive  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE32222
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     breast tumor  | 
     ER-  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE32222
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     breast tumour metastasis  | 
     Metastasis  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE32222
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     breast tumor  | 
     Non-responder  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE32222
              
            
          
            
            ...
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     breast tumor  | 
     Responder  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE32222
              
            
          
            
            ...
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF10A (breast epithelial cells)  | 
     Cells were lentivirally transduced with MYC-ERVD and stable pools were treated with 100nM 4-OHT for 24h.  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE59146
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF10A (breast epithelial cells)  | 
     Cells were lentivirally transduced with MYC-ERVD and stable pools were treated with solvent control for 24h.  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE59146
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF10A (breast epithelial cells)  | 
     Cells were lentivirally transduced with MYC-ER and stable pools were treated with solvent control for 24h.  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE59146
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     breast tumor  | 
     Female  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE104399
              
            
          
            
            ...
            
          
            
          
            
          
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     breast tumor  | 
     Male  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE104399
              
            
          
            
            ...
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     100 nM ICI for 30 min  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE108883
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     5 nM E2 for 30 min  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE108883
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     vehicle for 3h  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE108883
              
            
          
            
            ...
            
          
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     ICI for 3h  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE108883
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2 for 3h  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE108883
              
            
          
            
            ...
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     control  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109820
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     100nm E2 (45 min)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109820
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     100nm E2 (90 min)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109820
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     control  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109820
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     100nm E2 (45 min)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109820
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     100nm E2 (90 min)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109820
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     control  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109820
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     100nm E2 (45 min)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109820
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     100nm E2 (90 min)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109820
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     control  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109820
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     100nm E2 (45 min)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109820
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     100nm E2 (90 min)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109820
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Source: cJun - Tet cells; CellType: ERalpha-positive breast cancer cells; Treatment: ethanol 1hr;    | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE102410
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Source: cJun - Tet cells; CellType: ERalpha-positive breast cancer cells; Treatment: 17beta estradiol 10nM for 1hr;    | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE102410
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Source: cJun - Tet cells; CellType: ERalpha-positive breast cancer cells; Treatment: tamoxifen 1μM for 1hr;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE102410
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: vehicle(DMSO 2 hr); Passage: p19;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE103023
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 500nM RAD001 2hr; Passage: p19;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE103023
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 500 nM AZD201 2 hr; Passage: p19;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE103023
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: vehicle(DMSO 2 hr); Passage: p20;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE103023
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 500nM RAD001 2hr; Passage: p20;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE103023
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 500 nM AZD201 2 hr; Passage: p20;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE103023
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: vehicle(DMSO 2 hr); Passage: p21;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE103023
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 500nM RAD001 2hr; Passage: p21;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE103023
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 500 nM AZD201 2 hr; Passage: p21;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE103023
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: vehicle(DMSO 2 hr); Passage: p22;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE103023
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 500nM RAD001 2hr; Passage: p22;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE103023
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 500 nM AZD201 2 hr; Passage: p22;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE103023
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     CellType: Mammary gland adenocarcarcinoma epithelial ceslls derived from metastatic site Modifications: parental cells  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE107176
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MDA-MB-134 (invasive lobular breast carcinoma)  | 
     Treatment: DMSO Passage: between 10 and12 CellType: Epithelial ERalpha positive breast cancer cell line  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109103
              
            
          
            
            ...
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MDA-MB-134 (invasive lobular breast carcinoma)  | 
     Treatment: 100 nM estradiol (E2) for 1hr Passage: between 10 and12 CellType: Epithelial ERalpha positive breast cancer cell line  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109103
              
            
          
            
            ...
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MDA-MB-134 (invasive lobular breast carcinoma)  | 
     Treatment: a cocktail of 10 µM forskolin plus 100 µM 3-isobutyl-1-methylxanthine (FI) for 1hr Passage: between 10 and12 CellType: Epithelial ERalpha positive breast cancer cell line  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109103
              
            
          
            
            ...
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     Ishikawa (endometrial adenocarcinoma)  | 
     Treatment: 100 nM Dexamethasone and 10 nM Estradiol for 1 hour  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109891
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     Ishikawa (endometrial adenocarcinoma)  | 
     Treatment: 10 nM Estradiol for 1 hour  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109891
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     Ishikawa (endometrial adenocarcinoma)  | 
     Treatment: DMSO (vehicle) for 1 hour  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE109891
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     DMSO  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE115607
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     H3B-6545  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE115607
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Saturated H3B-6545  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE115607
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     800  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE115607
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Rad1901  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE115607
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     H3B-5942  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE115607
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Saturated H3B-5942  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE115607
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Tamoxifen  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE115607
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Fulvestrant  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE115607
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE115607
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     Treatment: Hormone-deprived media using RPMI1640 without phenol red and 10% charcoal-stripped FBS) for 5-7 days  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE116170
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     CellSubtype:Stable ESR1-YAP1 fusion expressing model Treatment: Hormone-deprived media using RPMI1640 without phenol red and 10% charcoal-stripped FBS) for 5-7 days  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE116170
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     CellSubtype: stable ESR1-PCDH11X fusion expressing model Treatment: Hormone-deprived media using RPMI1640 without phenol red and 10% charcoal-stripped FBS) for 5-7 days  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE116170
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     CellSubtype: stable ESR1-NOP2 fusion expressing model Treatment: hormone-deprived media using RPMI1640 without phenol red and 10% charcoal-stripped FBS) for 5-7 days  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE116170
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     CellSubtype: stable YFP-HA expressing model Treatment: Hormone-deprived media using RPMI1640 without phenol red and 10% charcoal-stripped FBS) for 5-7 days  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE116170
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: DMSO for 45 min  Genotype: wildtype TET2 Passage: 6-10   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE120756
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: E2 (estrogen) for 45 min  Genotype: wildtype TET2 Passage: 6-10   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE120756
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: DMSO for 45 min  Genotype: TET2 knockout Passage: 6-10   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE120756
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: E2 (estrogen) for 45 min  Genotype: TET2 knockout Passage: 6-10   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE120756
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: DMSO for 45 min  Genotype: wildtype TET2 Passage: 6-10   | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE120756
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: E2 (estrogen) for 45 min  Genotype: wildtype TET2 Passage: 6-10   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE120756
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MDA-MB-231 (breast adenocarcinoma)  | 
     treatment: E2, 100 nM, 0 min Genotype: ER-alfa wildtype  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE95121
              
            
          
            
            ...
            
          
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MDA-MB-231 (breast adenocarcinoma)  | 
     Treatment: E2, 100 nM, 45 min Genotype: ER-alfa wildtype  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE95121
              
            
          
            
            ...
            
          
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MDA-MB-231 (breast adenocarcinoma)  | 
     Treatment: E2, 100 nM, 0 min Genotype: ER-alfa L540Q  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE95121
              
            
          
            
            ...
            
          
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MDA-MB-231 (breast adenocarcinoma)  | 
     Treatment: E2, 100 nM, 0 min Genotype: ER-alfa L540Q  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE95121
              
            
          
            
            ...
            
          
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     Passsage: <10  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99479
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     Passsage: <10  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99479
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     Passsage: <10 Genotype: wt/R330fs mutant with CRISPR  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99479
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     Passsage: <10 Genotype: wt/R330fs mutant with CRISPR  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99479
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 10nM Estradiol + 10 nM DHT for 45 mins Genotype: ER+/PR+  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99626
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: Vehicle for 60 mins Genotype: ER+/PR+  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99626
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 10 nM Dexamethasone for 60 mins Genotype: ER+/PR+  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99626
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 15 mins of 10nM Estradiol and then 10nM Estradiol + 10 nM Dexamethasone for 60 mins Genotype: ER+/PR+  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99626
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 10 nM Aldosterone for 45 mins Genotype: ER+/PR+  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99626
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 10nM Estradiol + 10 nM Aldosterone for 45 mins Genotype: ER+/PR+  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99626
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     10nM Estradiol + 10 nM Dexamethasone  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99626
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: Vehicle for4 hrs Genotype: ER+/PR+  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99626
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 10 nM E2 for4 hrs Genotype: ER+/PR+  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99626
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 10 nM R5020 for45 mins Genotype: ER+/PR+  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99626
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 10 nM E2 + 10 nM R5020 for45 mins Genotype: ER+/PR+  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99626
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatmet: Vehicle, 45 min Genotype: ER+/PR+  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99626
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 10 nM Estradiol for 45 mins Genotype: ER+/PR+  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE99626
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: FA (control)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE114737
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment:  2 mM DSG for 25 mins  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE114737
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     primary breast cancer  | 
     Treatment:  2 mM DSG for 25 mins  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE114737
              
            
          
            
            ...
            
          
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     primary endometrium cancer  | 
     Treatment: FA (control)  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE114737
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     primary endometrium cancer  | 
     Treatment:  2 mM DSG for 25 mins  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE114737
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 10 nM 17-beta-estradiol for 30 mins Genotype: pS118-ER  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE117569
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: vehicle (0.01% EtOH) for 30 mins Genotype: pS118-ER  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE117569
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 10 nM 17-beta-estradiol for 30 mins Genotype: pS118-ER  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE117569
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: vehicle (0.01% EtOH) for 30 mins Genotype: pS118-ER  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE117569
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 10 nM 17-beta-estradiol for 30 mins Genotype: pS118-ER  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE117569
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: vehicle (0.01% EtOH) for 30 mins Genotype: pS118-ER  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE117569
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: 10 nM 17-beta-estradiol for 30 mins Genotype: wildtype ER  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE117569
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: vehicle (0.01% EtOH) for 30 mins Genotype: wildtype-ER  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE117569
              
            
          
            
            ...
            
          
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     B-cells  | 
     Genotype: wildtype; Strain: C57BL/6; Tissue: spleen;  | 
    
      
      
      Permissive
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE66424
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7L-P(immortalized breast epithelial cell line)  | 
     Treatment: untreated;  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE108787
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7L-P(immortalized breast epithelial cell line)  | 
     Treatment: treated with E2 for 1 hr;  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE108787
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7L-P(immortalized breast epithelial cell line)  | 
     Treatment: treated with E2 for 4 hrs;  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE108787
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7L-P(immortalized breast epithelial cell line)  | 
     Treatment: treated with E2 for 16 hrs;  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE108787
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7L-P(immortalized breast epithelial cell line)  | 
     Treatment: treated with E2 for 24 hrs;  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE108787
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: with Estrogen;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE117492
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     Treatment: with Estrogen +1,6-Hexanediol;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE117492
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     sperm  | 
     Strain: CD1;  | 
    
      
      
      Permissive
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE116855
              
            
          
            
            ...
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     uterus  | 
     Age: adult; Treatment: 250 ng E2 dissolved in 0.1 ml of normal saline for 6 hrs; Strain: C57BL/6J;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE125972
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     uterus  | 
     Age: adult; Treatment: 250 ng E2 dissolved in 0.1 ml of normal saline for 8 hrs; Strain: C57BL/6J;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE125972
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     uterus  | 
     Age: adult; Treatment: 250 ng E2 dissolved in 0.1 ml of normal saline for 12 hrs; Strain: C57BL/6J;   | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE125972
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     uterus  | 
     Age: 21 day; Treatment: 250 ng E2 dissolved in 0.1 ml of normal saline; Strain: C57BL/6J;   | 
    
      
      
      Permissive
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE125972
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     E2_TAM  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP000380
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     ZR-75-1 (invasive ductal carcinoma)  | 
     E2_TAM  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP000380
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP000901
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     LY2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP003844
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE14664
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     HCC-1428 (breast adenocarcinoma)  | 
     TLED  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE27300
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     TLED  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE27300
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     SHESR1  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE53531
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2_JQ1  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE55921
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68356
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE26083
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE33804
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE24166
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     liver  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE49993
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     uterus  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE49993
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     mammary gland  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE43415
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE49390
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE49390
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF10A (breast epithelial cells)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE59001
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     preantral follicles  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE62545
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE73320
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE74033
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE75779
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE75779
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     mammary gland  | 
     | 
    
      
      
      Permissive
      
     | 
    Mus musculus | 
    
      
        
          
            
              
              GSE77586
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE67295
              
            
          
            
            ...
            
          
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     patient-derived pleaural effusion  | 
     N/A  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE86538
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94031
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94031
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94031
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94031
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94031
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     endometrioid adenocarcinoma  | 
     | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE94031
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE25710
              
            
          
            
            ...
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE25710
              
            
          
            
            ...
            
          
            
          
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE25710
              
            
          
            
            ...
            
          
            
          
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE25710
              
            
          
            
            ...
            
          
            
          
            
          
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE116768
              
            
          
            
            ...
            
          
            
          
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7L-TamR(immortalized breast epithelial, tamoxifen resistant cell line)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE108787
              
            
          
            
            ...
            
          
        
      
        
      
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP000783
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     ZR-75-1 (invasive ductal carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP000783
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP003828
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE35109
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE41561
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE45822
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE48930
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68356
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     | 
     | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68356
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68356
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     | 
     | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68356
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP000209
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP000380
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2_TAM  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP000380
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     SHCRT_E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP000380
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     SHFOXA1_E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP000380
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     TAM  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP000380
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     TAMR  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP000380
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     TAMR_TAM  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP000380
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     | 
     glyc  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP002305
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     | 
     mrnahist  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP002305
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     GLYC  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP002305
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     MRNAHIST  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP002305
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     H3396 (breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE32349
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     H3396 (breast carcinoma)  | 
     ETOH  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE32349
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     SICTR_E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE40129
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     SIGATA_E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE40129
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     ZR-75-1 (invasive ductal carcinoma)  | 
     SICTR_E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE40129
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     ZR-75-1 (invasive ductal carcinoma)  | 
     SIGATA_E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE40129
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     | 
     tumor_BADOUTCOME  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE40867
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     | 
     tumor_GOODOUTCOME  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE40867
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     VCaP (prostate carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE43985
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     VCaP (prostate carcinoma)  | 
     E2_ERA  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE43985
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MDA-MB-134 (invasive lobular breast carcinoma)  | 
     ESTROGEN  | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE51022
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MDA-MB-134 (invasive lobular breast carcinoma)  | 
     ETOH  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE51022
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     LETR  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE54592
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     LETR_ANDRO  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE54592
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     LY2_ETOH  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE54592
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2_10M  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE54855
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2_120M  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE54855
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2_2M  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE54855
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2_40M  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE54855
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2_5M  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE54855
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE59530
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2_TNF  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE59530
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     SHCTR_E2_TNF  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE59530
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     SHFOXA1_E2_TNF  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE59530
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     TNF  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE59530
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE60270
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     SHCTR  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE60270
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     SHCTR_E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE60270
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     SHFOXA1_E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE60270
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     SHGATA3_E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE60270
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     PROG  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68355
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     R5020  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68355
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     PROG  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68355
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     R5020  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68355
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68356
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2PG  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68356
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE71276
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE72249
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE72249
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     ZR-75-1 (invasive ductal carcinoma)  | 
     E2  | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE72249
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP000209
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              ERP000380
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE54855
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE59530
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE60270
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68355
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68355
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE68356
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE71276
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     MCF7 (Invasive ductal breast carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE72249
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     T47D (invasive ductal carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE72249
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     | 
  
  
    
    | ESR1 | 
     ZR-75-1 (invasive ductal carcinoma)  | 
     | 
    
      
      
      Permissive
      
      Robust
      
     | 
    Homo sapiens | 
    
      
        
          
            
              
              GSE72249
              
            
          
        
      
     | 
    
      
        
        MA0112.3
        
      
     |